Dimerization of natively folded molecules drives misfolding and aggregation in Cys-depleted variants of cataract-associated human lens γD-crystallin
Yu Pu, Vanie Seecharan, Loy Hashimoto, Aslam Uddin, Eugene Serebryany
This study investigates how Cys depletion in γD-crystallin leads to misfolding and aggregation through dimerization, revealing a novel pathway for age-related cataract formation.
Journal of Biological Chemistry · Jun 9, 2026Peer-reviewedBiochemistry