Author

Aslam Uddin

Stony Brook UniversityORCID 0000-0002-6034-8223Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Eugene SerebryanyiD· 2 shared Loy Hashimoto· 1 shared Vanie SeecharaniD· 1 shared Yu Pu· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBiochemistry

Eugene SerebryanyORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedJun 9, 2026

Dimerization of natively folded molecules drives misfolding and aggregation in Cys-depleted variants of cataract-associated human lens γD-crystallin

Yu Pu, Vanie Seecharan, Loy Hashimoto…·Eugene Serebryany

This study investigates how Cys depletion in γD-crystallin leads to misfolding and aggregation through dimerization, revealing a novel pathway for age-related cataract formation.

1 citation

humanproteomics

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BiophysicsbioRxivPreprintJan 8, 2026

Disulfide engineering reveals unexpected pro- and anti-aggregation conformers of human α-synuclein

Aslam Uddin, Eugene Serebryany

This study uses disulfide engineering to identify pro- and anti-aggregation conformers of human α-synuclein, revealing previously unknown polymorphs and their functional impacts.

DOI 10.64898/2026.01.07.698305

humanprotein structure

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