Ultra-sensitive Mapping of Cell-free DNA-derived Methylomes Reveals Brain-specific Epigenetic Alterations Implicated in Alzheimer Disease
Xiaolong Cui, Alana V. Beadell, Shinya Tasaki, Ana Werneck Capuano, Zhou Zhang, Lu Gao, Brian C.‐H. Chiu, Chuan He, David Alan Bennett, Zoe Arvanitakis, Wei Zhang
The paper demonstrates the feasibility of detecting methylation differences in serum-derived cell-free DNA between Alzheimer's disease and non-AD controls using LABS, linking these changes to brain-specific epigenetic alterations in AD.
medRxiv · Oct 26, 2026 · PreprintGenetic & Genomic Medicine