Genetic & Genomic MedicinemedRxivPreprint
Ultra-sensitive Mapping of Cell-free DNA-derived Methylomes Reveals Brain-specific Epigenetic Alterations Implicated in Alzheimer Disease
Xiaolong Cui, Alana V. Beadell, Shinya Tasaki…·Wei Zhang
The paper demonstrates the feasibility of detecting methylation differences in serum-derived cell-free DNA between Alzheimer's disease and non-AD controls using LABS, linking these changes to brain-specific epigenetic alterations in AD.
DOI 10.64898/2026.10.24.26366278