A thalamostriatal brake counteracts cortical recruitment of striatal ensembles in levodopa-induced dyskinesia
Jie Wang, Xin-Yu Tu, Jing-Xue Liang, J Sun, Wenying Xu, Yongling Wang, Xin Yi, Yu Wu, Xin-Ni Li, Ying-Xiao Liu, Zhenguo Liu, Wei‐Guang Li, Lu Song
This study identifies M2 and PF as opposing afferents to striatal ensembles in LID, showing M2 promotes dyskinesia while PF suppresses it through distinct synaptic mechanisms.
bioRxiv · Jul 27, 2026 · PreprintNeuroscience