Wei‐Guang Li

A thalamostriatal brake counteracts cortical recruitment of striatal ensembles in levodopa-induced dyskinesia

This study identifies M2 and PF as opposing afferents to striatal ensembles in LID, showing M2 promotes dyskinesia while PF suppresses it through distinct synaptic mechanisms.

Neuropeptide Y co-opts neuronal ensembles for memory lability and stability

The paper identifies NPY+ interneurons in the ventral hippocampus that regulate memory extinction through distinct sub-ensembles via fast and slow inhibition.

Neuron-astrocyte Coupling in Lateral Habenula Mediates Depressive-like Behaviors

This study identifies a stress-induced positive feedback loop in the LHb-LC axis mediated by astrocytic calcium signaling, which influences depressive-like behaviors in mice.

An ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits

This study shows that remimazolam in the thalamic nucleus reuniens disrupts fear extinction by altering hippocamposeptal circuits.

Hijacking a dedicated entorhinal-hippocampal extinction circuit to remove traumatic memory

This study identifies a specific LEC-vCA1 pathway that uses low gamma-band oscillations to facilitate fear extinction and shows its therapeutic potential through DBS and tACS in a PTSD mouse model.

Dynamic tripartite construct of interregional engram circuits underlies forgetting of extinction memory

The paper shows that forgetting of extinction memory involves a dynamic shift in the connectivity of engram circuits between the mPFC, BLA, and vHPC.