Jie Wang

This study identifies M2 and PF as opposing afferents to striatal ensembles in LID, showing M2 promotes dyskinesia while PF suppresses it through distinct synaptic mechanisms.

This study uses dynamic caging to link live-cell behavior with transcriptional responses across perturbations, revealing new insights into immune and inflammatory gene regulation.

The paper shows microglia preserve fear memory by selectively pruning extinction-ensemble synapses through local signaling cues during memory retrieval.

This study identifies BRD8 as an epigenetic suppressor of tumor-intrinsic immunity in liver cancer, showing its depletion enhances immunogenicity and sensitizes tumors to immunotherapy.

This study identifies human tRNA splicing elements that enable efficient intracellular auto-circularization of RNA, providing a framework for circRNA production.

The paper identifies a novel SOX9 variant in the TAM domain linked to axial skeletal dysplasia and scoliosis, showing reduced protein stability and recapitulating human phenotypes in mice.

The paper identifies a human-specific mutation linked to height and basal metabolic rate, showing its evolutionary timing and functional impact through dietary changes.

The paper examines genetic dependence features of genes and their role in determining pathogenicity and clinical features of genetic diseases.

SynLethDB 2.0 is a database that compiles synthetic lethal gene pairs and related knowledge to aid in anticancer drug discovery, including over 16,000 new synthetic lethal interactions.

This study compares DNA methylation patterns in myocardial tissue from individuals with and without Down syndrome, identifying differentially methylated CpG sites and regions.