Membrane progesterone receptor signaling reverses hyperglycemia and insulin resistance in obese mice
Nancy Nader, Lubna Zarif, Shereena Sherif, Jawaher Al-Hamaq, Dalal Al Qahtani, Raphael J Courjaret, Fang Yu, Hanan H. Abunada, Praveen Babu Vemulapalli, Sunkyu Choi, Frank Schmidt, Khaled Machaca
This study shows that activating membrane progesterone receptors improves glucose homeostasis and insulin sensitivity in obese mice through AMPK-dependent metabolic reprogramming.
bioRxiv · Mar 30, 2026 · PreprintPhysiology