Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activity
Giorgio Anselmi, Vincent Frontera, Christina Rode, Andrew Jarratt, Naeema T. Mehmood, Matthew Nicholls, Luca Buttler, Stella Antoniou, John O’Rourke, Emanuele Azzoni, John A. Stamatoyannopoulos, Ditsa Levanon, Yoram Groner, Marella F. T. R. De Bruijn
The paper identifies a Runx1 enhancer that distinguishes hematopoietic stem cells (HSCs) from progenitor cells (HPCs) in the mouse dorsal aorta using enhancer-reporter models and single-cell multiome analysis.
Cell Reports · Jul 30, 2026Peer-reviewedDevelopmental Biology