Author

Matthew Nicholls

University of OxfordORCID 0000-0003-1161-5409Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein design· 1

Frequent Co-Authors

Emanuele AzzoniiD· 2 shared Marella F. T. R. De BruijniD· 2 shared Alastair SmithiD· 1 shared Alessandro FantiniD· 1 shared Alessandro MuratoreiD· 1 shared Alison DominguesiD· 1 shared Ana CumanoiD· 1 shared Andrew Jarratt· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersDevelopmental Biology

Emanuele AzzoniORCID

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3 papers

Recent·Most cited

Developmental BiologyCell ReportsPeer-reviewedJul 30, 2026

Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activity

Giorgio Anselmi, Vincent Frontera, Christina Rode…·Marella F. T. R. De Bruijn

The paper identifies a Runx1 enhancer that distinguishes hematopoietic stem cells (HSCs) from progenitor cells (HPCs) in the mouse dorsal aorta using enhancer-reporter models and single-cell multiome analysis.

DOI 10.1016/j.celrep.2026.117737

mousescRNA-seq

𝕏 PostBluesky

Synthetic BiologybioRxivPreprintOct 27, 2025

TRANCERs: Engineering enhancers into autonomous tissue-specific expression cassettes

Elisa K. Barrow Molina, Alastair Smith, Paco López‐Cuevas…·Jim R. Hughes

TRANCERs convert enhancers into autonomous tissue-specific promoters, enabling precise and programmable gene expression for research and therapy.

1 citation

experimental assaygene regulatory network inference

𝕏 PostBluesky

Developmental BiologybioRxivPreprintJul 11, 2024

Hemogenic endothelium of the vitelline and umbilical arteries is the major contributor to mouse fetal lympho-myelopoiesis

Cristiana Barone, Giulia Quattrini, Roberto Orsenigo…·Emanuele Azzoni

The paper identifies hemogenic endothelium in vitelline and umbilical arteries as a major source of fetal lympho-myeloid progenitors in mice, showing their transient contribution before definitive HSCs emerge.

3 citations

mousescRNA-seq

𝕏 PostBluesky