Intra-host IRES heterogeneity shapes hepatitis C virus translation through epistatic and population-level effects
Natalia Echeverría, Paula Perbolianachis, Fabiana Gámbaro, Lucas Amaya, Martín Sóñora, Álvaro Fajardo, Nelia Hernandez, Juan Cristina, Evandro Ferrada, Pilar Moreno, Gonzalo Moratorio
This study shows that natural variation in HCV IRES affects translation efficiency through epistasis and population-level effects, challenging reliance on dominant sequences.
bioRxiv · Aug 9, 2026 · PreprintMolecular Biology