Evandro Ferrada

This study shows that natural variation in HCV IRES affects translation efficiency through epistasis and population-level effects, challenging reliance on dominant sequences.

The paper analyzes physicochemical features of transmembrane protein-protein interfaces to determine their topology, finding that amino acid composition and secondary structure are key predictors.

The paper creates a functional landscape of human solute carriers by integrating multi-omics data and curated knowledge, assigning functions to each SLC and providing a web-accessible resource.