ENGRAILED-1 transcription factor exerts a paracrine neurotrophic activity on adult spinal cord α-motoneurons.
Mélanie Lebœuf, Stephanie E. Vargas Abonce, Eugénie Pezé-Heidsieck, Edmond Dupont, Lucia Jimenez-Alonso, Kenneth L. Moya, Alain Prochiantz
This study shows ENGRAILED-1 has paracrine neurotrophic effects on spinal cord α-motoneurons, with loss of function leading to motoneuron loss and limb weakness.
EMBO Reports · Jul 6, 2023Peer-reviewedNeuroscience