Eugénie Pezé-Heidsieck

ENGRAILED-1 transcription factor exerts a paracrine neurotrophic activity on adult spinal cord α-motoneurons.

This study shows ENGRAILED-1 has paracrine neurotrophic effects on spinal cord α-motoneurons, with loss of function leading to motoneuron loss and limb weakness.

Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition

The paper shows that human-specific genes SRGAP2B/C regulate synaptic neoteny in human cortical neurons by modulating SYNGAP1 levels.

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression

The paper shows that Engrailed-1 protects dopaminergic neurons from degeneration by repressing LINE-1 expression, which is linked to oxidative stress-induced DNA damage.