Alain Prochiantz

This study shows that Pml loss worsens NEK1-linked ALS, while Pml induction reduces disease symptoms by clearing Nek1t aggregates.

The paper shows that modulating perineuronal nets in the motor cortex of Parkinson's disease mice improves motor function when combined with environmental enrichment and training.

The paper compares molecular signatures of juvenile critical period plasticity and adult enhanced plasticity in parvalbumin cells, finding distinct translatomic profiles and condition-specific pathways.

This study shows ENGRAILED-1 has paracrine neurotrophic effects on spinal cord α-motoneurons, with loss of function leading to motoneuron loss and limb weakness.

This study shows that choroid plexus APP affects adult brain proliferation and behavior in mice, with reduced proliferation and cognitive deficits observed after APP overexpression.

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

This study shows that sustained Gadd45b overexpression in mice causes DNA methylation changes, heterochromatin disorganization, DNA damage, and dopaminergic neuron death, linking chromatin alterations to neurodegeneration.

This study shows that OTX2 synthesized in the choroid plexus and secreted into cerebrospinal fluid regulates anxiety-like behaviors in mice through non-cell-autonomous mechanisms.

The paper examines diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex, finding increased PNN and PV staining intensity during the dark phase.

This study shows OTX2 promotes both survival and axon regeneration of adult retinal ganglion cells in vitro and in vivo.

The paper shows that OTX2 non-cell autonomous activity in the retina affects inner retinal function and causes reduced visual acuity without altering retinal structure or photoreceptor physiology.

This study shows that ENGRAILED-1 promotes motoneuron survival and motor function by preventing denervation and neuronal death.

This study shows that five homeoproteins protect embryonic midbrain and striatal neurons from oxidative stress-induced DNA damage and cell death, but not non-neuronal cells.

This study shows that extracellular Pax6 non-cell autonomously regulates Cajal-Retzius cell migration in the developing mouse neocortex by affecting directionality, distance, and depth of migration.

The paper shows OTX2 secreted by the choroid plexus regulates adult neurogenesis by affecting astrocytes and extracellular matrix, reducing newborn neurons in the olfactory bulb.

The paper shows that Engrailed-1 protects dopaminergic neurons from degeneration by repressing LINE-1 expression, which is linked to oxidative stress-induced DNA damage.

The paper shows that OTX2 homeoprotein transfer regulates visual cortex plasticity in juvenile mice by modulating Gadd45b/g expression and epigenetic states.