dsRBD Redesign: A Targeted Strategy for Inhibition of RNA Helicase DHX9
Nina Lang, Emily C. Freund, Lucie Haene, Kristian Schweimer, Janosch Hennig
This paper redesigns dsRBD domains to inhibit DHX9 helicase activity by targeting its autoregulatory interface, offering a computationally efficient strategy for therapeutic development.
bioRxiv · Feb 15, 2026 · PreprintBiochemistry