Emily C. Freund

The paper designs de novo TIM barrels with structural lids to create active sites for enzymatic function, achieving high catalytic efficiency.

This paper redesigns dsRBD domains to inhibit DHX9 helicase activity by targeting its autoregulatory interface, offering a computationally efficient strategy for therapeutic development.

This study shows that repeated RNA-lipoplex vaccination sustains functional CD8 T cells in tumors and improves therapeutic outcomes.

The paper investigates how immunodominance affects CD8+ T cell differentiation and hierarchy after RNA vaccination, finding that dominant responses influence subdominant ones through cross-competition.

The paper identifies regulators of inflammatory macrophage states and shows that TNF mRNA m6A modification controls its stability and contributes to disease.

The paper identifies Zn72D as a regulator of ADAR-mediated RNA editing in Drosophila neurons and shows its conservation in mammals.

The paper identifies trans regulators of ADAR1 and ADAR2 using BioID and mass-spectrometry, validating novel interactors as RNA editing regulators.