Janosch Hennig

This study shows that RNA recognition by the Sxl protein depends on a dynamic conformational ensemble rather than a single structure, and perturbing this balance impairs RNA binding.

The paper investigates the energy landscape of coupled folding and binding in intrinsically disordered proteins, finding that electrostatic interactions compensate for energetic frustration.

The paper develops a deep mutational scanning framework to map variants to molecular functions in RBM20, identifying functional hotspots and therapeutic strategies for dilated cardiomyopathy.

This paper redesigns dsRBD domains to inhibit DHX9 helicase activity by targeting its autoregulatory interface, offering a computationally efficient strategy for therapeutic development.

The paper uses single-molecule fluorescence microscopy to study mRNP assembly mechanisms in translation repression, revealing synergistic roles of RNA-binding proteins.

The paper shows that different structures of alpha-synuclein fibrils affect how Hsc70 chaperones disaggregate them, influencing protein quality control and aggregation.

This study investigates how ParB activates ParA ATPase activity during bacterial chromosome segregation in Myxococcus xanthus by analyzing their molecular interactions.

AlphaDesign uses AlphaFold to design novel protein structures, including monomers, dimers, and higher-order complexes, showing structural integrity and conformational switching capabilities.

This study identifies the molecular interactions of UPF1 in histone mRNA decay, showing how SLBP and UPF2 regulate its unwinding activity and degradation efficiency.

The paper shows Staufen directly interacts with Tm1 to regulate oskar mRNA transport by modulating kinesin-1 activity in Drosophila oocytes.

This study identifies PUN motifs in yeast Loc1p that cooperate to catalyze RNA folding and drive phase separation, suggesting a role in RNA and DNA-related processes across species.

This paper identifies the RNA binding specificity of Hrp48, showing it binds the msl-2 mRNA 3' UTR independently of Sxl and Unr downstream of their binding sites.

This study reveals how the dsRBD2 domain of the DExH-type helicase maleless orchestrates RNA unwinding through structural transitions, independent of ATP.

The paper shows how multiple RNA binding domains in Unr mediate poly(A) specificity and interact with poly(A) binding protein during translation regulation.

The paper shows RNA regulates ENO1 enzyme activity, affecting glycolysis and stem cell differentiation in human and mouse cells.

The paper characterizes the quaternary hunchback mRNA repression complex formed by Brat, Pum, and Nanos, revealing its flexibility and independent binding of RNA components.

The paper identifies the molecular mechanism by which vault RNA1-1 regulates p62 oligomerisation, essential for selective autophagy.