Partial Bypass of Frataxin Deficiency by ISCU M141I Restores Cytosolic and Nuclear FeS Cluster Assembly
Valentine Mosbach, Nunziata Maio, Lucie Hermet, Nadège Diedhiou, Adele Hennick, Laure Dall'Agnol, Laurence Reutenauer, Lenaic Marczak, Marie‐Christine Birling, Aurélie Eisenmann, Alain Martelli, Hélène M. Puccio
The paper shows that the ISCU M141I variant partially rescues Fe-S cluster assembly in FXN-deficient cells, preserving nuclear and cytosolic Fe-S proteins but not mitochondrial function.
Cell Death and Differentiation · Aug 6, 2026Peer-reviewedCell Biology