Valentine Mosbach

The paper shows that the ISCU M141I variant partially rescues Fe-S cluster assembly in FXN-deficient cells, preserving nuclear and cytosolic Fe-S proteins but not mitochondrial function.

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

This study shows that using Cas9 to induce a double-strand break at CTG trinucleotide repeats leads to chromosomal rearrangements, highlighting risks of using Cas9 near microsatellites.