A dual role in virion attachment and entry makes the human cytomegalovirus gHgLgO trimer the central player in virion infectivity
Lena Thiessen, Rita Garuti, Lucie Kubic, Miwako Kösters, Divya Amarambedu Selvakumar, Thomas Krey, Irene Görzer, Thomas Fröhlich, Barbara Adler
The paper identifies gHgLgO as the central player in HCMV infectivity by showing its role in HSPG binding and infectivity, challenging previous views on gB and gMgN complexes.
PLoS Pathogens · Jul 24, 2025Peer-reviewedMicrobiology