Acute Inhibition of Adipose Triglyceride Lipase by NG497 Dysregulates Insulin and Glucagon Secretion from Human Islets
Lucy B Kim, Siming Liu, Syreine Richtsmeier, Michał Górniak, Anamika Vikram, Yumi Imai
This study investigates how acute inhibition of ATGL with NG497 affects insulin and glucagon secretion from human islets, finding that chronic mechanisms dominate insulin reduction while acute inhibition reduces glucagon secretion.
Endocrinology · May 12, 2025Peer-reviewedCell Biology