Siming Liu

This study identifies ABHD5 as a critical co-activator of PNPLA2 in pancreatic beta cells, showing it supports glucose-stimulated lipolysis and insulin secretion.

This study investigates how acute inhibition of ATGL with NG497 affects insulin and glucagon secretion from human islets, finding that chronic mechanisms dominate insulin reduction while acute inhibition reduces glucagon secretion.

This study investigates the role of PLIN5 phosphorylation in mice, finding it dispensable for lipid metabolism gene upregulation during fasting but necessary for IRS2 expression in males.

This study shows that PLIN2 regulates lipophagy in beta cells to prevent fatty acid accumulation in mitochondria, which impairs insulin secretion and mitochondrial function.

This study shows that reducing Perilipin2 in beta cells impairs insulin secretion and mitochondrial function under nutritional stress.