Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilities
Alexandra Livanova, Luca Azzolin, Francesco Cambuli, Francesca Chemi, Chela T. James, Antonello Ferrazzano, Francesco Rusconi, Sabrina L. D’Agosto, Ilaria Mulas, Giovanni Randon, Michele Prisciandaro, Alessandra Raimondi, Filippo Ghelardi, Margherita Ambrosini, Paolo Manca, , Andrea Sottoriva
This study examines the epigenetic evolution of colorectal cancer and its microenvironment, identifying new therapeutic targets through single-cell analysis and functional validation.
bioRxiv · Aug 11, 2026 · PreprintCancer Biology