Francesco Cambuli

Epigenetic evolution of colorectal cancer and its microenvironment reveals new vulnerabilities

This study examines the epigenetic evolution of colorectal cancer and its microenvironment, identifying new therapeutic targets through single-cell analysis and functional validation.

Tissue and cellular spatiotemporal dynamics in colon aging

This study creates a spatial and cellular atlas of the colon across age groups using spatial transcriptomics and single nucleus RNA-seq, identifying age-related molecular gradients and multicellular programs.

Single-Cell RNA Sequencing and Inferred Protein Activity Analysis Reveal a Distinct Tumor Phenotype in Early-Onset Colorectal Cancer Patients

The paper compares early-onset and late-onset colorectal cancer using scRNA-seq and VIPER to identify distinct stromal and epithelial features in early-onset tumors.

A single-cell atlas of the mouse and human prostate reveals heterogeneity and conservation of epithelial progenitors

This study creates a single-cell atlas of mouse and human prostate epithelium, identifying conserved progenitor populations and anatomical relationships between species.