Fluid shear stress modulates endocytic pathways and junctional targeting of tumor-derived extracellular vesicles in endothelial cells
Nícolas Jones Villarinho, Bong Hwan Sung, Ana Sayuri Yamagata, Ramon Handerson Gomes Teles, Luiz Da Silva, André Zelanis, Murilo de Souza Salardani, Gisela Ramos Terçarioli, Vitória Samartin Botezelli, Júlia de Moura Bernardi, Mário Costa Cruz, Ruy Gastaldoni Jaeger, Alissa M. Weaver, Vanessa M. Freitas
This study investigates how fluid shear stress affects the uptake and junctional targeting of tumor-derived extracellular vesicles by endothelial cells, identifying clathrin- and caveolin-mediated endocytosis as key pathways.
bioRxiv · May 5, 2026 · PreprintCancer Biology