Alissa M. Weaver

Extracellular vesicle cross-linking coupled with solid-phase purification facilitates discovery of ribonucleoprotein complexes assembled on EV RNAs.

This paper introduces two methods, EV-CLASP and EV(r)-CLASP, to study RNP complexes on EV RNAs, revealing post-transfer interactions and intra-vesicular compositions.

Fluid shear stress modulates endocytic pathways and junctional targeting of tumor-derived extracellular vesicles in endothelial cells

This study investigates how fluid shear stress affects the uptake and junctional targeting of tumor-derived extracellular vesicles by endothelial cells, identifying clathrin- and caveolin-mediated endocytosis as key pathways.

Small Extracellular Vesicle Cargoes Associated with Lymph Node Metastasis in Head and Neck Cancer

This study identifies SEV cargoes associated with lymph node metastasis in HNSCC using proteomic profiling and mouse models, showing their potential as biomarkers and functional mediators.

Secreted exosomes induce filopodia formation

This study identifies exosomes carrying THSD7A as regulators of filopodia formation in both cancer cells and neurons, mediated through Cdc42 activation.

Exosomes are specialized vehicles to induce fibronectin assembly

This study shows that exosomes initiate fibronectin assembly in vitro and in vivo, reducing tumor growth and fibrosis.

Macromolecular Diamidobenzimidazole Conjugates Activate STING

This study shows that macromolecular diABZI conjugates activate STING in vitro and in vivo, with similar potency to small molecule agonists, suggesting new strategies for STING agonist delivery.

5-Fluorouracil Treatment Represses Pseudouridine-Containing Small RNA Export into Extracellular Vesicles

This study shows that 5-FU treatment alters the export and base modifications of small RNAs in extracellular vesicles from colorectal cancer cells.

Cancer Hallmarks Define a Continuum of Plastic Cell States between Small Cell Lung Cancer Archetypes

This study shows SCLC cells exist in a continuum of plastic states rather than discrete subtypes, with gene expression patterns linked to cancer hallmarks and potential therapeutic targets.