Author

Lukas Badertscher

AstraZeneca (Sweden)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Organism:mouse· 1 Approach:statistical model· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Abdel Wahad Bidar· 1 shared Alexandra PopaiD· 1 shared Amir Taheri‐GhahfarokhiiD· 1 shared Anders LundiniD· 1 shared Andrew S. BoghossianiD· 1 shared Anju Kombara· 1 shared Anna Schantz· 1 shared Babak Alaei-MahabadiiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Abdel Wahad Bidar

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Genetic dependencies associated with transcription factor activities in human cancer cell lines

Venu Thatikonda, Verena Supper, Johannes Wachter, Onur Kaya, Anju Kombara, Ceren Bilgilier, Madhwesh C. Ravichandran, Jesse Lipp, Rahul Sharma, Lukas Badertscher, Andrew S. Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Sarah Grosche, , Alexandra Popa

The paper identifies genetic vulnerabilities linked to transcription factor activities in cancer cell lines using CRISPR knockout data and validates targets associated with TEAD1.

Cell Reports · Apr 30, 2024Peer-reviewedBioinformatics

ObLiGaRe doxycycline Inducible (ODIn) Cas9 system driving pre-clinical drug discovery, from design to cancer treatment

Anders Lundin, Michelle J. Porritt, Himjyot Jaiswal, Frank Seeliger, Camilla Johansson, Abdel Wahad Bidar, Lukas Badertscher, Emma Jane Davies, Elizabeth L. Hardaker, Carla P. Martins, Therése Admyre, Amir Taheri‐Ghahfarokhi, Jenna Bradley, Anna Schantz, Babak Alaei-Mahabadi, , Marcello Maresca

This paper introduces an inducible CRISPR-Cas9 system for preclinical drug discovery, enabling controlled genome editing in mice to model cancer and test therapies.

bioRxiv · Apr 6, 2020 · PreprintGenomics