Author

Sarah Grosche

Boehringer Ingelheim (Austria)ORCID 0000-0002-7658-0932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ralph A. NeumülleriD· 2 shared Alexandra PopaiD· 1 shared Andrew S. BoghossianiD· 1 shared Anju Kombara· 1 shared Barbara Hopfgartner· 1 shared Barbara MairiD· 1 shared Catarina Mörck· 1 shared Ceren Bilgilier· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Ralph A. NeumüllerORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintJan 15, 2026

DUSP4 knockdown in BRAF V600E mutant colorectal cancer induces cell cycle arrest and halts tumor growth

Barbara Hopfgartner, Monika Kriz, Donát Alpár…·Sarah Grosche

This study shows that DUSP4 knockdown causes cell cycle arrest and halts tumor growth in BRAF V600E mutant colorectal cancer models but does not lead to tumor regression.

DOI 10.64898/2026.01.15.699635

humanexperimental assay

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BioinformaticsCell ReportsPeer-reviewedApr 30, 2024

Genetic dependencies associated with transcription factor activities in human cancer cell lines

Venu Thatikonda, Verena Supper, Johannes Wachter…·Alexandra Popa

The paper identifies genetic vulnerabilities linked to transcription factor activities in cancer cell lines using CRISPR knockout data and validates targets associated with TEAD1.

3 citations

humanCRISPR screen

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Developmental BiologybioRxivPreprintAug 15, 2019

A Canal-Associated Neuron cAMP signalling pathway that regulates C. elegans larval development

Jason Chien, Fred W. Wolf, Sarah Grosche…·Catarina Mörck

The paper identifies a cAMP signaling pathway involving CANs and ACY-2 that promotes larval development in C. elegans by inhibiting KIN-29 through PKA activation.

DOI 10.1101/733618

C. elegansstatistical model

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