Author

Elizabeth Ann Mittendorf

Brigham and Women's HospitalORCID 0000-0002-9762-8536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:spatial domain detection· 3 Approach:statistical model· 3 Assay:scRNA-seq· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Adrienne Gropper WaksiD· 3 shared Carlos Wagner S WanderleyiD· 3 shared Jennifer L. GuerrieroiD· 3 shared Kenichi ShimadaiD· 3 shared Sara M. TolaneyiD· 3 shared Adam NelsoniD· 2 shared Daniel E. MichaudiD· 2 shared Esther Ritah OgayoiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCancer Biology

Adrienne Gropper WaksORCID

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4 papers

Recent·Most cited

Spatial/molecular heterogeneity and treatment response in HER2+ early breast cancer: Translational analyses from the DAPHNe trial

Emily Chen, Ilana Miriam Schlam, Kaoru Shimada, Tianyu Li, Esther Ritah Ogayo, Ashka Patel, Janae Davis, Jia‐Ren Lin, Austin Schultz, Madeline G Townsend, Kelly F Zheng, Carlos Wagner S Wanderley, Ricardo Pastorello, Felicia New, Evelyn Metzger, , Adrienne Gropper Waks

The paper analyzes HER2+ breast cancer using multi-platform data to identify molecular predictors of response to neoadjuvant therapy and highlights intra-tumoral heterogeneity and immune exclusion mechanisms.

bioRxiv · Sep 18, 2026 · PreprintCancer Biology

A Single-Cell Peripheral Immune Atlas Spanning High-Risk Lesions to Invasive Breast Cancer in Black and White Women

Fangyuan Chen, Esther Ritah Ogayo, Tasnim Rahman, Abigail Recko, Hanna Starobinets, Miloš R. Spasić, Adrienne Marie Parsons, Peter van Galen, EA Mittendorf, Sandra S. McAllister

The paper constructs a single-cell peripheral immune atlas for Black and White women across breast disease states, identifying race-associated immune differences linked to chronic inflammation and immune aging in Black patients.

bioRxiv · May 7, 2026 · PreprintCancer Biology

APOE Tumor-Associated Macrophages and CD4-DOCK4 T Cells Reveal Distinct Microenvironmental Features in HER2-Low and HER2-0 Hormone Receptor-Positive Breast Cancer

Carlos Wagner S Wanderley, Daniel E. Michaud, Kenichi Shimada, Adam Nelson, Jingxin Fu, Stuart J. Schnitt, Sara M. Tolaney, Elizabeth Ann Mittendorf, Romualdo Barroso‐Sousa, Adrienne Gropper Waks, Paolo Tarantino, Jennifer L. Guerriero

The paper identifies distinct immune and stromal features in HR+ HER2-low and HER2-0 breast cancers using molecular and multiplexed imaging.

bioRxiv · Sep 4, 2025 · PreprintCancer Biology

An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer

Kenichi Shimada, Daniel E. Michaud, Yvonne Xiaoyong Cui, Kelly Zheng, Jonathan L. Goldberg, Zhenlin Ju, Stuart J. Schnitt, Ricardo Pastorello, Lukas D. Kania, John Hoffer, Jeremy L. Muhlich, Nhan Hyun, Robert Krueger, Alexander P. Gottlieb, Adam Nelson, , Jennifer L. Guerriero

This study identifies an estrogen receptor signaling program in HR+ breast cancer that suppresses immune responses by reducing T cell infiltration and HLA expression, suggesting therapeutic targets to enhance immunogenicity.

bioRxiv · Nov 23, 2024 · PreprintCancer Biology