S-Adenosyl-D-methionine as a Non-Physiological Substrate for a Wide Range of SAM-Dependent Enzymes
Philipp Germer, Lukas Gericke, Lars-Hendrik Koeppl, Ziruo Zou, Emely Jockmann, Marco Kuge, Katrin Zoller, Hannah Herrmann, Ronja Fuderer, Michael K. F. Mohr, Agnes Bartels, Göksu Oral, Peer Lukat, Gunhild Layer, Michael Müller, , Jennifer N. Andexer
This study investigates the ability of SAM-dependent enzymes to accept D-SAM instead of L-SAM, finding that several enzymes can utilize D-SAM and highlighting implications for enzyme engineering.
ChemBioChem · Jul 26, 2026Peer-reviewedBiochemistry