SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1-XBP1 Signaling Under ER Stress
Qianqian Ying, Yongchen Chen, Luochen Shen, Yang Xu, Ruilin Tian
SPLiCR-seq identifies novel regulators of IRE1-XBP1 signaling under ER stress, revealing GADD34 as a key modulator with therapeutic potential in CAR-T cell immunotherapy.
Nature Communications · Dec 19, 2025Peer-reviewedGenetics