Constitutive NF-kB Activation is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells that Resist Viral Oncolysis
Alaa A. Abdelmageed, Jack Smerczynski, Lute Douglas, Tori L. Russell, Matthew C. Morris, Stephen Dewhurst, Maureen C. Ferran
This study shows that PC3 prostate cancer cells resist VSV oncolysis due to constitutive NF-kB activation, which is amplified by VSV infection through I{kappa}B--independent mechanisms.
bioRxiv · Sep 23, 2025 · PreprintCancer Biology