Stephen Dewhurst

This study identifies an NF-κB-driven anti-apoptotic network in PC3 prostate cancer cells that contributes to resistance against oncolytic VSV, suggesting combination therapies may enhance virotherapy efficacy.

This study shows that PC3 prostate cancer cells resist VSV oncolysis due to constitutive NF-kB activation, which is amplified by VSV infection through I{kappa}B--independent mechanisms.

This study uses single-cell RNA sequencing to analyze age and cell population-specific responses to SARS-CoV-2 infection in lung epithelial cells, identifying differences in innate immune signaling between pediatric and adult tissues.

This study shows that olcegepant reduces weight loss and IL-6 release in older mice infected with SARS-CoV-2, suggesting potential neuroprotective effects against coronavirus-induced inflammation.

This paper develops new CRISPR-Cas13a variants and crRNA design strategies to improve RNA-detection specificity, achieving better discrimination of SARS-CoV-2 strains.