Author

Alaa A. Abdelmageed

University of Rochester MedicineORCID 0009-0009-3891-3642Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

Maureen C. FerraniD· 2 shared Stephen DewhurstiD· 2 shared Jack SmerczynskiiD· 1 shared Lute Douglas· 1 shared Matthew C. MorrisiD· 1 shared Tori L. RusselliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

Maureen C. FerranORCID

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2 papers

Recent·Most cited

Cancer BiologyVirusesPeer-reviewedOct 23, 2026

Multi-omics Profiling Reveals an NF-κB-Driven Anti-apoptotic Network Underlying Resistance to Oncolytic VSV in Prostate Cancer Cells

Alaa A. Abdelmageed, Stephen Dewhurst, Maureen C. Ferran

This study identifies an NF-κB-driven anti-apoptotic network in PC3 prostate cancer cells that contributes to resistance against oncolytic VSV, suggesting combination therapies may enhance virotherapy efficacy.

DOI 10.3390/v18111182

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 23, 2025

Constitutive NF-kB Activation is Amplified by VSV in Aggressive PC3 Prostate Cancer Cells that Resist Viral Oncolysis

Alaa A. Abdelmageed, Jack Smerczynski, Lute Douglas…·Maureen C. Ferran

This study shows that PC3 prostate cancer cells resist VSV oncolysis due to constitutive NF-kB activation, which is amplified by VSV infection through I{kappa}B--independent mechanisms.

DOI 10.1101/2025.09.23.678061

humanbulk RNA-seq

𝕏 PostBluesky