Targeting GFPT2 to reinvigorate immunotherapy in EGFR-mutated NSCLC
Luyao Ao, Wenjing Jia, Qixing Gong, Jiawen Cui, Jun Wang, Ying Yu, Chenghao Fu, Haobin Li, Jia Wei, Ruiqi L. Wang, Feiyi Wang, Xin Chun Shang, Yantong Li, Shencun Fang, Guangji Wang, , Jiali Liu
This study identifies GFPT2 as a metabolic checkpoint in EGFR-mutated NSCLC that promotes immune evasion, and shows that targeting GFPT2 enhances PD-1 blockade therapy.
bioRxiv · Mar 1, 2024 · PreprintCancer Biology