Author

Ying Yu

Tianjin Medical UniversityORCID 0000-0002-6476-1752Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ying Yu7 papers · University of Minnesota

Biology Disciplines

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Biophysics· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Assay:GWAS summary statistics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Angela R Brooks-WilsoniD· 1 shared Brad McNeney· 1 shared Heng ZhangiD· 1 shared Hongtao ZhuiD· 1 shared Hongxi YangiD· 1 shared Kexin CheniD· 1 shared Lin WangiD· 1 shared Lingling ZhangiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenetics

Angela R Brooks-WilsonORCID

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3 papers

Recent·Most cited

Structural Basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex

Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

This study presents cryo-EM structures of the Cas5-HNH/Cascade complex, revealing its DNA cleavage mechanism and the role of zinc-finger and divalent ions in enzyme activity.

Nature Communications · Feb 4, 2025Peer-reviewedBiophysics

Penalized Logistic Regression Analysis for Genetic Association Studies of Binary Phenotypes

Ying Yu, Siyuan Chen, Samantha Jean Jones, Rawnak Hoque, Olga Vishnyakova, Angela R Brooks-Wilson, Brad McNeney

The paper introduces a penalized logistic regression method using log-F priors to reduce bias in genetic association studies with binary phenotypes, showing lower bias and mean squared error in simulations.

Human Heredity · Jan 1, 2022Peer-reviewedGenetics

Coagulation factors and COVID-19 severity: Mendelian randomization analyses and supporting evidence

Yao Zhou, Xinyi Qian, Zipeng Liu, Hongxi Yang, Tong Liu, Kexin Chen, Yaogang Wang, Pak Chung Sham, Ying Yu, Mulin Jun Li

This paper uses Mendelian randomization to identify causal links between coagulation factors and COVID-19 severity, finding VWF and ADAMTS13 as significant factors.

Signal Transduction and Targeted Therapy · Jun 7, 2021Peer-reviewedGenetic & Genomic Medicine