Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption
Lorena F Fernandes, Chariya Peeyatu, Ben Dickie, Yu Siong Ho, Lydia A Thompson, N. Hernández-Lobato, Neus Lozano, Kostas Kostarelos, Thomas Kisby
This study identifies a post-operative window of blood-brain barrier disruption at the glioblastoma resection margin and demonstrates enhanced chemotherapy delivery using liposomal nanomedicines during this period.
bioRxiv · Mar 29, 2025 · PreprintPharmacology & Toxicology