Kostas Kostarelos

Plasma membrane-associated graphene oxide as aplatform for modulating signalling through cell-surfacereceptors: an integrin-focused proof-of-concept study

This study demonstrates that graphene oxide can be used as a membrane-associated platform to modulate integrin signaling in cancer cells, reducing motility through RGD peptide association.

An artefact-resilient wide bandwidth bidirectional graphene neural interface

This paper presents a bidirectional neural interface combining graphene technologies for recording and stimulation, showing that recording performance is not compromised during stimulation.

Interplay between material properties and cellular effects drives distinct pattern of interaction of graphene oxide with cancer and non-cancer cells

This study investigates how graphene oxide interacts differently with cancer and non-cancer cells, showing that GO uptake and effects depend on material properties and cellular responses.

Graphene Micro-transistor Arrays Reveal Perfusion-Dependent Electrophysiological and Haemodynamic Signatures of Cortical Spreading Depolarizations in Ischaemic Stroke

The paper uses graphene micro-transistor arrays and imaging to study how blood flow and electrical activity change during brain injuries in mice.

Targeting therapeutic nanoparticles to the glioblastoma resection margin by harnessing post-operative spatiotemporal blood-brain barrier disruption

This study identifies a post-operative window of blood-brain barrier disruption at the glioblastoma resection margin and demonstrates enhanced chemotherapy delivery using liposomal nanomedicines during this period.

Flexible graphene-based neurotechnology for high-precision deep brain mapping and neuromodulation in Parkinsonian rats

This study evaluates flexible graphene-based microelectrodes for deep brain stimulation and recording in Parkinsonian rats, showing high signal quality and potential for adaptive neuromodulation.

Full bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene micro-transistor depth neural probes

This paper introduces flexible graphene micro-transistor depth neural probes for recording infraslow and high-frequency neuronal activity in rodents, demonstrating their utility in epilepsy research.

Selective Liposomal Transport Through Blood Brain Barrier Disruption in Ischaemic Stroke Reveals Two Distinct Therapeutic Opportunities

This study shows liposomes can selectively enter the brain after stroke through two distinct BBB disruption phases, offering new therapeutic opportunities for targeted drug delivery.

Exposure to graphene oxide sheets alters the expression of reference genes used for real-time RT-qPCR normalization

This study evaluates the impact of graphene oxide exposure on reference gene expression in human and mouse cells, showing significant dysregulation in ribosomal proteins and common calibrators.

Non-viral induction of transient cell reprogramming in skeletal muscle to enhance tissue regeneration

This study induces transient cell reprogramming in mouse skeletal muscle using plasmid DNA to enhance tissue regeneration after injury.