Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells
Chloe G. Myers, Hema Viswambharan, Natalie J. Haywood, Katherine Bridge, Samuel J. Turvey, Tom Armstrong, Lydia Lunn, Paul J. Meakin, Karen E. Porter, Eva M. Clavane, David J. Beech, Richard M. Cubbon, Stephen Bentley Wheatcroft, Martin J. McPhillie, Tarik Issad, , Katie J. Simmons
This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.
Molecular and Cellular Endocrinology · Oct 16, 2024Peer-reviewedCell Biology