Author

Hema Viswambharan

University of LeedsORCID 0000-0002-7616-5026Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

David J. BeechiD· 2 shared Katherine BridgeiD· 2 shared Katie J. SimmonsiD· 2 shared Mark T. KearneyiD· 2 shared Martin J. McPhillieiD· 2 shared Natalie J. HaywoodiD· 2 shared Richard M. CubboniD· 2 shared Alexander-Francisco BrunsiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCell Biology

David J. BeechORCID

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3 papers

Recent·Most cited

Tissue-specific endothelial cell heterogeneity in human type 2 diabetes

Alexander-Francisco Bruns, Oliver Ian Brown, Hema Viswambharan, Klaus Karl Witte, Sam Straw, John Gierula, Chew Weng Cheng, Katherine Bridge, Natalie J Haywood, Anna Skromna, Natallia Makava, Lauren F Daly, Matthew Bourn, Jeanne F Rivera, Nora Almuhim, , Mark T. Kearney

The paper examines transcriptomic heterogeneity of microvascular endothelial cells in subcutaneous adipose tissue and skeletal muscle in type 2 diabetes, finding stress in SAT but not SkM.

bioRxiv · Dec 3, 2025 · PreprintCell Biology

Targeting Tenascin-C-Toll-like Receptor 4 signalling with Adhiron-derived small molecules - a viable strategy for reducing fibrosis in Systemic Sclerosis

Thembaninkosi G. Gaule, Katie J. Simmons, Kieran Walker, Francesco Del Galdo, Rebecca L. Ross, Hema Viswambharan, Jahnavi Krishnappa, Jack Pacey, Martin J. McPhillie, Darren Charles Tomlinson, Azhar Maqbool

This paper identifies small molecules targeting the Tenascin C fibrinogen-like globe domain to reduce fibrosis in systemic sclerosis by inhibiting Toll-like receptor 4 signaling.

Bioorganic Chemistry · Nov 20, 2025Peer-reviewedPhysiology

Small molecule modulation of insulin receptor-insulin like growth factor-1 receptor heterodimers in human endothelial cells

Chloe G. Myers, Hema Viswambharan, Natalie J. Haywood, Katherine Bridge, Samuel J. Turvey, Tom Armstrong, Lydia Lunn, Paul J. Meakin, Karen E. Porter, Eva M. Clavane, David J. Beech, Richard M. Cubbon, Stephen Bentley Wheatcroft, Martin J. McPhillie, Tarik Issad, , Katie J. Simmons

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

Molecular and Cellular Endocrinology · Oct 16, 2024Peer-reviewedCell Biology