Katie J. Simmons

This study identifies eight structurally diverse KCNT1 channel inhibitors through virtual screening and experimental validation, offering potential new treatments for KCNT1-associated epilepsy.

This study develops a pipeline using Adhirons to guide small molecule discovery against viral targets, identifying hits for Crimean-Congo Haemorrhagic Fever Virus and Influenza A Virus.

This paper identifies small molecules targeting the Tenascin C fibrinogen-like globe domain to reduce fibrosis in systemic sclerosis by inhibiting Toll-like receptor 4 signaling.

This study identifies two existing drugs that reduce KCNT1 channel activity and seizure activity in Drosophila models, suggesting potential new treatments for KCNT1-epilepsy.

This paper identifies a small molecule that reduces IR:IGF-1R hybrid formation in human endothelial cells, increasing Akt phosphorylation and altering PI3-kinase signaling.

The paper uses site-directed mutagenesis to identify key residues involved in IR-IGF1R hybrid receptor formation, showing mutations reduce hybrid affinity and support rational drug design.

The paper identifies three SNPs in EFCAB4B (CRACR2A) associated with increased risk of COVID-19 fatality through missense mutations affecting protein structure and function.

The paper reports the cryo-EM structure of human TRPC5 bound to the xanthine inhibitor Pico145, revealing its interaction with a conserved lipid binding site and elucidating the mechanism of TRPC1/4/5 modulation.