Over-the-counter fiber supplementation associates with metabolic and microbial shifts in rectal mucosa
David A. Alvarado, Lydia Okyere, Amber O’Connor, Maura Walsh, Siting Chen, Liana V. Tsikitis, Christopher A. Gaulke
This study examines how over-the-counter fiber supplements affect the rectal mucosal environment by altering microbiota, SCFA levels, and host gene expression in patients with benign anorectal disease.
bioRxiv · Sep 9, 2026 · PreprintMicrobiology