Lauren N. Lucas

This study shows that dietary cholesterol and saturated fat together drive fibrosing MASH via gut microbiota changes, specifically increasing Parasutterella spp. and activating hepatic stellate cells.

This study investigates BSH activity in human gut bacteria and finds that some strains can directly dehydrogenate conjugated bile acids to produce conjugated secondary bile acids, challenging the idea that deconjugation is a prerequisite for further modifications.

The paper examines sex differences in gut microbiota and bile acid composition in mice, finding distinct microbial diversity and portal bile acid profiles between males and females.

This study identifies allosteric regulation of pyruvate kinase in Bacillus subtilis as critical for efficient gluconeogenesis by preventing metabolic conflicts and carbon overflow.