Author

M GOTTESMAN

National Institutes of Health

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Abraham J. MortoniD· 1 shared Chao-Ming HsiehiD· 1 shared Di XiaiD· 1 shared Fei Zhou· 1 shared Jingyu ZhaniD· 1 shared Lothar EsseriD· 1 shared Rick K HuangiD· 1 shared Robert W. RobeyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Abraham J. MortonORCID

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1 paper

Recent·Most cited

Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4

Jingyu Zhan, Chao-Ming Hsieh, Lothar Esser, Zabrina C. Lang, Abraham J. Morton, Robert W. Robey, Fei Zhou, Suresh V. Ambudkar, Rick K Huang, M GOTTESMAN, Di Xia

This study reveals the conformational dynamics of zebrafish Abcb4 using cryo-EM, showing its open-and-close motion and substrate-binding flexibility, which may explain its polyspecificity.

Nature Communications · May 30, 2026Peer-reviewedBiochemistry