BiochemistryNature CommunicationsPeer-reviewed
Functional Implications of the Conformational Landscape of a Multidrug Transporter Revealed by Structures of Zebrafish Abcb4
Jingyu Zhan, Chao-Ming Hsieh, Lothar Esser…·Di Xia
This study reveals the conformational dynamics of zebrafish Abcb4 using cryo-EM, showing its open-and-close motion and substrate-binding flexibility, which may explain its polyspecificity.