Inflammatory signals from fatty bone marrow supports the early stages of DNMT3a driven clonal hematopoiesis
N. Zioni, A. Bercovich, N. Chapal-Ilani, A. Solomon, E. Petrovich, M. .Sacma, H. Geiger, M. Scheller, C. Müller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, L. Shlush
This study shows that fatty bone marrow (FBM) promotes DNMT3A-driven clonal hematopoiesis by enhancing inflammatory signals like IL-6, which can be inhibited by blocking the IL-6 receptor.
bioRxiv · Jan 13, 2022Cancer Biology