Author

L. Shlush

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Solomon· 2 shared M. Scheller· 2 shared N. Kaushansky· 2 shared A. Ang Houle· 1 shared A. Bercovich· 1 shared B. Lin· 1 shared C. Mueller-Tidow· 1 shared C. Müller-Tidow· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

A. Solomon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

J.-S. Kim, S. Trzebanski, S.-H. Shin, N. C. Ilani, N. Kaushansky, M. Scheller, A. Solomon, Z. Liu, O. Aust, S. Boura-Halfon, L. Amann, M. Prinz, F. Ginhoux, R. Avraham, C. Mueller-Tidow, , S. Jung

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

bioRxiv · Nov 16, 2023Immunology

Inflammatory signals from fatty bone marrow supports the early stages of DNMT3a driven clonal hematopoiesis

N. Zioni, A. Bercovich, N. Chapal-Ilani, A. Solomon, E. Petrovich, M. .Sacma, H. Geiger, M. Scheller, C. Müller-Tidow, D. Lipka, E. Shlush, M. Minden, N. Kaushansky, L. Shlush

This study shows that fatty bone marrow (FBM) promotes DNMT3A-driven clonal hematopoiesis by enhancing inflammatory signals like IL-6, which can be inhibited by blocking the IL-6 receptor.

bioRxiv · Jan 13, 2022Cancer Biology

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

K. Skead, A. Ang Houle, S. Abelson, M. Agbessi, V. Bruat, B. Lin, D. Soave, L. Shlush, S. Wright, J. Dick, Q. Morris, P. Awadalla

The paper models positive and negative selection in blood cells to explain why some people with ARCH do not progress to AML, finding that passenger mutation burden influences clonal dominance.

Nature Communications · Aug 13, 2021Peer-reviewedCancer Biology