M. A. Cherian

The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer

This study shows that inhibiting heparanase increases heparan sulfate levels, enhancing eATP and chemotherapy response in TNBC cells.

Potent Estrogen Receptor β Agonists with Inhibitory Activity In Vitro, Fail to Suppress Xenografts of Endocrine-Resistant Cyclin-dependent Kinase 4/6 inhibitor-Resistant Breast Cancer Cells

The paper tests the in vivo efficacy of estrogen receptor β agonists combined with tamoxifen in endocrine-resistant breast cancer models, finding no tumor volume reduction despite in vitro success.

Sulfatase 2 Inhibition Sensitizes Triple-Negative Breast Cancer Cells to Chemotherapy Through Augmentation of Extracellular ATP

This study shows that sulfatase 2 inhibition enhances chemotherapy effectiveness in TNBC by increasing extracellular ATP release and reducing cancer-initiating cells.

Activity of Estrogen Receptor β Agonists in Therapy-Resistant Estrogen Receptor-Positive Breast Cancer

This study shows that selective ERβ agonists reduce viability of ER+ breast cancer cells and suggest their potential as a therapeutic strategy when combined with ER blockade.

Augmentation of extracellular ATP synergizes with chemotherapy in triple negative breast cancer

This study shows that increasing extracellular ATP through P2RX channels and inhibiting ATPases enhances chemotherapy effectiveness in triple-negative breast cancer cells.