Heterogeneity in signaling pathway activity within primary and between primary and metastatic breast cancer
M. A. Inda, P. van Swinderen, A. van Brussel, C. B. Moelans, W. Veraheagh, H. van Zon, E. C. den Biezen-Timmermans, J. W. Bikker, P. J. van Diest, A. van de Stolpe
This study measures signaling pathway activity in breast cancer samples to assess heterogeneity within primary tumors and between primary and metastatic sites, finding that microscale variation is higher in some pathways and that metastases show less correlation with primary tumors.
bioRxiv · Jul 27, 2020Cancer Biology